Danae Schulz

This paper shows that Bdf3 activation at the EP promoter in bloodstream Trypanosoma brucei increases EP1 transcript levels, supporting its role in initiating transcription during differentiation to the procyclic stage.

This study shows that inhibiting bromodomain proteins in insect stage African trypanosomes causes transcriptome changes and disrupts VSG gene silencing, similar to developmental progression.

The paper investigates dynamic changes in Bdf3 chromatin occupancy during Trypanosoma brucei differentiation from bloodstream to insect stage, finding increased occupancy at genes involved in surface protein remodeling.

The paper creates a T. brucei ORFeome and Gain-of-Function library to identify genes promoting survival during melarsoprol treatment, finding 57 genes including a known drug target and novel genes related to resistance mechanisms.

This study identifies small molecules that inhibit trypanosome growth and induce surface remodeling by promoting differentiation into insect-stage parasites.