Author

Tianyi Yang

Beckman Research InstituteORCID 0000-0002-0413-4167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Elizaveta MukhalevaiD· 2 shared Nagarajan VaidehiiD· 2 shared Ning MaiD· 2 shared Veerabahu ShanmugasundaramiD· 2 shared Wenyuan WeiiD· 2 shared Andréi S. RodiniD· 1 shared Dahlia R. WeissiD· 1 shared Indira R. Sivaraj· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Elizaveta MukhalevaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Protein Frustration Reveals Active Sites in Co-Evolved GPCR:G Protein Complexes and in Engineered Targeted Degrader Complexes

Wenyuan Wei, Roland Del Mundo, Tianyi Yang, Elizaveta Mukhaleva, Indira R. Sivaraj, Veerabahu Shanmugasundaram, Sergio Branciamore, Andréi S. Rodin, Sivaraj Sivaramakrishnan, Ning Ma, Nagarajan Vaidehi

The paper identifies frustrated residues in GPCR:G protein interfaces and engineered degrader complexes, showing higher frustration in engineered interfaces.

bioRxiv · Jun 27, 2025 · PreprintBiophysics

Insights From Protein Frustration Analysis Of BRD4-Cereblon Degrader Ternary Complexes Show Separation of Strong from Weak Degraders

Tianyi Yang, Elizaveta Mukhaleva, Wenyuan Wei, Dahlia R. Weiss, Ning Ma, Veerabahu Shanmugasundaram, Nagarajan Vaidehi

This study uses protein frustration analysis to identify key residues distinguishing strong from weak BRD4-Cereblon degraders.

RSC Medicinal Chemistry · Jan 1, 2025Peer-reviewedBiophysics