Molecular BiologyBiochemical JournalPeer-reviewed
Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration
Alexander Curtis Jones, Alexandr P. Kornev, Jui‐Hung Weng…·Alexandra C. Newton
The paper shows how a single amino acid change in PKCβ's C1A domain can switch between cancer-promoting and neurodegenerative effects by altering autoinhibition and degradation.
6 citations