Alexandr P. Kornev

This study identifies a catalytically inactive PKCα mutation that drives chordoid glioma by rewiring cellular interactions and impairing cell junction function.

The paper investigates the role of the C-β4 loop in protein kinase structure and dynamics, showing its importance in hydrophobic spine architecture and communication between kinase lobes.

The paper shows how a single amino acid change in PKCβ's C1A domain can switch between cancer-promoting and neurodegenerative effects by altering autoinhibition and degradation.

The paper evaluates centrality metrics in amino acid networks of protein kinase A, showing that traditional network construction methods are less effective than using conserved spatial patterns.