Author

Gerard Manning

3C Research (United Kingdom)ORCID 0000-0002-5087-9151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Christopher R. HorneiD· 2 shared James M. MurphyiD· 2 shared John W. ScottiD· 2 shared Laura F. DagleyiD· 2 shared Lucy J. Mather· 2 shared Samuel N. YoungiD· 2 shared Toby A. DiteiD· 2 shared Abner Gonzalez Castro· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Christopher R. HorneORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity

Christopher R. Horne, Tingting Wang, Samuel N. Young, Toby A. Dite, Hunter G. Nyvall, Sushant Suresh, Katherine A. Davies, Abner Gonzalez Castro, Vineet Vaibhav, Lucy J. Mather, Laura F. Dagley, Matthew J. Belousoff, Gerard Manning, Anthony R. Means, John E. Burke, , James M. Murphy

The paper identifies an unconventional mechanism where Ca2+-CaM binds CHK2 kinase to inhibit its activity, contrasting with its typical role in promoting kinase activity.

Biochemical Journal · Sep 26, 2025Peer-reviewedBiochemistry

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

Christopher R. Horne, Toby A. Dite, Samuel N. Young, Lucy J. Mather, Laura F. Dagley, Jared Lee Johnson, Tomer M. Yaron, Emily M. Huntsman, Leonard A. Daly, Dominic P. Byrne, Antonia L. Cadell, Boaz H. Ng, Jumana M. Yousef, Dylan H. Multari, Lianju Shen, , James M. Murphy

The paper identifies allosteric regulation of PSKH1 kinase activity by Ca2+ sensor proteins, showing both activation and suppression by different sensors.

Proceedings of the National Academy of Sciences · Feb 18, 2025Peer-reviewedBiochemistry

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

Alexander Curtis Jones, Alexandr P. Kornev, Jui‐Hung Weng, Gerard Manning, Susan Serota Taylor, Alexandra C. Newton

The paper shows how a single amino acid change in PKCβ's C1A domain can switch between cancer-promoting and neurodegenerative effects by altering autoinhibition and degradation.

Biochemical Journal · Aug 8, 2023Peer-reviewedMolecular Biology