Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular Origin
Ilianna Zoi, Memoona Rajput, Adrián Holguín-Horcajo, Malak Haidar, Davide Brusa, Ken Chu, Jane Xie, Mario A. Shields, Sofia Ferreira, Ben Z. Stanger, Laura Donatella Attardi, Janel L. Kopp, Marc P. Stemmler, Rémy Nicolle, Meritxell Rovira, Patrick Jacquemin
This study identifies a DNA methylation signature preserved during pancreatic carcinogenesis that distinguishes PDAC origins and influences tumor behavior.
bioRxiv · Mar 7, 2025 · PreprintCancer Biology