Laura Donatella Attardi

This paper develops a small molecule, TRAP-1, that activates mutant p53 by forming a ternary complex with BRD4, leading to p53 target gene upregulation and inhibition of cancer cell growth.

This paper shows that LKB1 is essential for ENS development by reducing oxidative stress and p53 activity, leading to hypoganglionosis and digestive issues when LKB1 is lost.

The paper identifies ZMAT3 and CDKN1A as key hubs in the p53 tumor suppression network through integrative multiomic analyses in a mouse model.

This study identifies a DNA methylation signature preserved during pancreatic carcinogenesis that distinguishes PDAC origins and influences tumor behavior.

This study shows that Ptpn14 deficiency in mice causes female-specific Hippo pathway defects, including corneal lesions, uterine defects, and organ abnormalities, with conserved roles in humans.

The paper uses spatial transcriptomics and proteomics to identify claudin-4 as a theranostic target in pancreatic cancer, showing its increased expression and suitability for molecular imaging.

This study shows that p53 TAD1 regulates the DNA damage response in endothelial cells to prevent radiation-induced cardiac injury.

This study identifies a p53-dependent translational program that explains tissue-selective phenotypes in ribosomopathies by regulating 4E-BP1 and altering the translatome.

The paper specifies TP53-specific ACMG/AMP variant classification guidelines, reducing variants of uncertain significance from 28% to 12%.

This study uses CRISPR/Cas9 to edit hematopoietic stem cells to express iduronidase, correcting Mucopolysaccharidosis type I in mice.