Janel L. Kopp

Endogenous insulin mediates dynamic coordination between pancreatic cancer and systemic metabolism

This study shows that endogenous insulin in pancreatic cancer tumors affects tumor growth and systemic metabolism, with differential effects based on diet and mouse sex.

Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular Origin

This study identifies a DNA methylation signature preserved during pancreatic carcinogenesis that distinguishes PDAC origins and influences tumor behavior.

Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

The paper shows that ECM and cell-cell adhesion coordinate to regulate islet aggregation, architecture, and functional maturation during development.