This study introduces a DNA-encoded library screening method called DEL Zipper to improve RNA-targeted small molecule screening by reducing DNA-RNA interaction signals.

11 citations

experimental assaydrug response / drug discovery

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GeneticsNature GeneticsPeer-reviewedApr 1, 2021

A resource of targeted mutant mouse lines for 5,061 genes

Marie‐Christine Birling, Atsushi Yoshiki, David J. Adams…·Sandy Teichmann

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

110 citationstop 1%

mouseexperimental assay

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Molecular BiologyThe CRISPR JournalPeer-reviewedDec 1, 2020

Improving FnCas12a genome editing by exonuclease fusion

Yongqiang Wu, Qichen Yuan, Yufeng Zhu…·Ziru Yin

The paper improves FnCas12a genome editing by fusing it with an exonuclease, enhancing its knockout efficiency in human cells.

33 citations

humanwhole-genome sequencing

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GeneticsThe American Journal of Human GeneticsPeer-reviewedOct 24, 2019

The human-specific BOLA2 duplication modifies iron homeostasis and anemia predisposition in chromosome 16p11.2 autism patients

Giuliana Giannuzzi, Paul Joseph Schmidt, Eleonora Porcu…·Alexandre Reymond

The paper investigates how BOLA2 duplication in chromosome 16p11.2 affects iron homeostasis and anemia risk in autism patients, finding associations with anemia and iron deficiency.

50 citations

humanmouse

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