Allan Bradley

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

This study creates a mouse model with human APOBEC3 genes to study their expression and anti-viral functions, showing human-like regulation and functional responses.

The paper investigates how Cas9-induced large deletions and small indels are regulated, showing their connection through repair mechanisms and locus-specific factors.

The paper shows that inserting short introns into transgenes improves their expression by reducing cryptic splicing, particularly for the SARS-CoV-2 Spike protein.

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.