Nicholas A. Sumpter

Circulating immune signatures reveal targetable inflammatory pathways in anaplastic thyroid carcinoma

This study identifies systemic inflammation and proinflammatory cytokine profiles in anaplastic thyroid carcinoma, showing their role in tumor survival and suggesting therapeutic targeting.

Testing for Causal Association between Serum Urate, Gout, and Prostatic Cancer in European Males

The paper uses Mendelian randomization to test causal links between serum urate, gout, and prostate cancer in European males, finding a causal effect of gout on prostate cancer but not of urate.

Local genetic covariance between serum urate and kidney function obtained from local Bayesian regressions.

This paper uses local Bayesian regressions to identify genomic regions with significant genetic covariance between chronic kidney disease and hyperuricemia, finding both novel and previously reported shared loci.

SNVformer: An Attention-based Deep Neural Network for GWAS Data

This paper introduces SNVformer, a Transformer-based model for GWAS data that predicts gout from SNVs with 83% AUROC, showing promise for scalable genotype-phenotype association analysis.