Tony Raymond Merriman

The paper uses Mendelian randomization to test causal links between serum urate, gout, and prostate cancer in European males, finding a causal effect of gout on prostate cancer but not of urate.

The paper reports a rare splice-site variant in TNNT2 found in Oceanian ancestry individuals, highlighting the need for diverse genomic datasets to avoid misclassification of variants.

The paper identifies novel CYP2D6 variants and suballeles in New Zealand Māori and Pacific populations, highlighting the high frequency of CYP2D6*71.

The paper identifies a stop-gain variant in BTNL9 associated with lower HDL-C and higher triglycerides in Polynesian populations.

This paper uses local Bayesian regressions to identify genomic regions with significant genetic covariance between chronic kidney disease and hyperuricemia, finding both novel and previously reported shared loci.

The paper examines the direct and indirect effects of rs373863828 on type 2 diabetes and fasting glucose in Polynesians, finding BMI mediates part of its effect.

The paper identifies a population-specific missense variant in CETP that lowers CETP activity and improves lipid profile, similar to loss-of-function mutations.

This study investigates the role of ABCG2 variants in gout progression from hyperuricemia, finding a stronger association with gout than with urate levels.

This paper identifies 15 novel serum urate loci and links them to 44 genes, revealing new molecular mechanisms of urate control through genomic and eQTL analysis.

The paper identifies a high rate of rare copy number variants in women with earthquake-induced stress cardiomyopathy, suggesting potential genetic predisposition.

The paper replicates an association between the CREBRF rs373863828 minor allele and increased BMI but reduced T2D risk in New Zealand Polynesian adults, similar to findings in Samoan populations.

The paper develops a method for HLA-B typing using nanopore sequencing and demonstrates its application in Maori and Polynesian populations.