Simon T. Alford

BLIMPS enables high-speed, high-resolution imaging of presynaptic Ca2+ dynamics in both excitatory and inhibitory neurons using lattice light sheet microscopy and genetically encoded calcium indicators.

The paper analyzes Ca2+ channel activity at lamprey reticulospinal synapses, showing a small number of channels trigger neurotransmitter release.

This paper investigates how two co-localized G protein-coupled receptors, GABAB and 5-HT1B, differentially modulate synaptic transmission in presynaptic terminals through distinct mechanisms.

The paper quantifies single action potential-evoked Ca2+ signals in CA1 pyramidal neuron presynaptic terminals and models their dynamics and interactions.

This study shows that disrupting Gβγ-SNARE interaction in mice leads to impaired gait, nociception, and hippocampal function, highlighting its role in GPCR-mediated presynaptic inhibition.