Zack Zurawski

BLIMPS enables high-speed, high-resolution imaging of presynaptic Ca2+ dynamics in both excitatory and inhibitory neurons using lattice light sheet microscopy and genetically encoded calcium indicators.

The paper shows that GABAB autoreceptors suppress neurotransmitter release during repetitive stimulation via the Gβγ-SNARE pathway, distinct from exogenous agonist effects.

This paper investigates how two co-localized G protein-coupled receptors, GABAB and 5-HT1B, differentially modulate synaptic transmission in presynaptic terminals through distinct mechanisms.

This study shows that disrupting Gβγ-SNARE interaction in mice leads to impaired gait, nociception, and hippocampal function, highlighting its role in GPCR-mediated presynaptic inhibition.