Disabling Gβγ SNARE interaction in transgenic mice disrupts GPCR-mediated presynaptic inhibition leading to physiological and behavioral phenotypes.
Zack Zurawski, Analisa D. Thompson Gray, Lillian J. Brady, Brian Page, Emily Church, Nicholas A. Harris, Michael R. Dohn, Yun Young Yim, Karren Hyde, Douglas P. Mortlock, Danny G. Winder, Simon T. Alford, Carrie K. Jones, Heidi E. Hamm
This study shows that disrupting Gβγ-SNARE interaction in mice leads to impaired gait, nociception, and hippocampal function, highlighting its role in GPCR-mediated presynaptic inhibition.
bioRxiv · Mar 11, 2018 · PreprintNeuroscience