Robert McManus

Serum UCHL1, GFAP, and NfL track tyrosine hydroxylase loss in substantia nigra in two Rat Models of Parkinsons Disease

Preservation of dopamine neurotransmission during nigrostriatal neuron loss in rat Parkinson model: evidence for increased dopamine signaling in substantia nigra

The paper investigates compensatory mechanisms in dopamine signaling during nigrostriatal neuron loss in a rat Parkinson model, finding that dopamine levels are preserved in the substantia nigra despite significant TH loss.

Moderate intensity aerobic exercise in 6-OHDA-lesioned rats alleviates established motor deficits and reduces neurofilament light and glial fibrillary acidic protein serum levels without increased striatal dopamine or tyrosine hydroxylase protein

This study shows moderate intensity aerobic exercise improves motor deficits and reduces blood biomarkers in a Parkinson's rat model without increasing striatal dopamine or tyrosine hydroxylase.

Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression

The paper evaluates aging's effect on motor and cognitive impairments in PINK1 knockout rats, finding decreased nigral dopamine and tyrosine hydroxylase with age, but not in striatum.

Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling

This study examines changes in GDNF receptor expression in the striatum and substantia nigra following a nigrostriatal lesion in rats, finding differential expression patterns of GFR-1 and RET that may impact GDNF therapeutic efficacy.

Nigral-specific increase in ser31 tyrosine hydroxylase phosphorylation offsets dopamine loss and forestalls hypokinesia onset during progressive nigrostriatal neuron loss

The paper investigates how increased ser31 tyrosine hydroxylase phosphorylation in the substantia nigra compensates for dopamine loss and delays hypokinesia onset in a rat model of Parkinson's disease.