NeurosciencebioRxivPreprint
Serum UCHL1, GFAP, and NfL track tyrosine hydroxylase loss in substantia nigra in two Rat Models of Parkinsons Disease
Isabel Soto, Robert McManus, Walter Navarrete…·Michael F. Salvatore
1 citation
Author
Michael F. Salvatore
University of North Texas Health Science CenterORCID 0000-0003-0217-5093Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2022-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 43 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- NeurosciencebioRxivPreprint
Preservation of dopamine neurotransmission during nigrostriatal neuron loss in rat Parkinson model: evidence for increased dopamine signaling in substantia nigra
Ashley Galfano, Robert McManus, Walter Navarrete…·Michael F. Salvatore
The paper investigates compensatory mechanisms in dopamine signaling during nigrostriatal neuron loss in a rat Parkinson model, finding that dopamine levels are preserved in the substantia nigra despite significant TH loss.
DOI 10.1101/2025.09.12.675909 - NeuroscienceExperimental NeurologyPeer-reviewed
Moderate intensity aerobic exercise in 6-OHDA-lesioned rats alleviates established motor deficits and reduces neurofilament light and glial fibrillary acidic protein serum levels without increased striatal dopamine or tyrosine hydroxylase protein
Ella Anle Kasanga, Isabel Soto, Ashley Centner…·Michael F. Salvatore
This study shows moderate intensity aerobic exercise improves motor deficits and reduces blood biomarkers in a Parkinson's rat model without increasing striatal dopamine or tyrosine hydroxylase.
14 citations - NeuroscienceExperimental NeurologyPeer-reviewed
Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression
Isabel Soto, Robert McManus, Walter Navarrete…·Michael F. Salvatore
The paper evaluates aging's effect on motor and cognitive impairments in PINK1 knockout rats, finding decreased nigral dopamine and tyrosine hydroxylase with age, but not in striatum.
7 citations - NeuroscienceFrontiers in NeurosciencePeer-reviewed
PINK1 knockout rats show premotor cognitive deficits measured through a complex maze
Isabel Soto, Vicki A. Nejtek, David Peter Siderovski, Michael F. Salvatore
The paper tests cognitive deficits in PINK1 knockout rats using a modified T-maze, finding increased errors and slower performance compared to wild-type rats.
7 citations - NeuroscienceExperimental NeurologyPeer-reviewed
Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling
Ella Anle Kasanga, Yoonhee Han, Walter Navarrete…·Michael F. Salvatore
This study examines changes in GDNF receptor expression in the striatum and substantia nigra following a nigrostriatal lesion in rats, finding differential expression patterns of GFR-1 and RET that may impact GDNF therapeutic efficacy.
15 citations - NeurosciencebioRxiv
Nigral-specific increase in ser31 tyrosine hydroxylase phosphorylation offsets dopamine loss and forestalls hypokinesia onset during progressive nigrostriatal neuron loss
Ella Anle Kasanga, Yoonhee Han, Marla K. Shifflet…·Michael F. Salvatore
The paper investigates how increased ser31 tyrosine hydroxylase phosphorylation in the substantia nigra compensates for dopamine loss and delays hypokinesia onset in a rat model of Parkinson's disease.
15 citations