Cell BiologybioRxivPreprint
Glucagon dysfunction in the liver induces hyperplasia of PP cells and the production of glucagon and pancreatic polypeptide double-positive cells
Yuko Nakagawa, Takuro Horii, Ayako Fukunaka…·Yoshio Fujitani
The paper shows that glucagon dysfunction in the liver leads to PP cell hyperplasia and the emergence of GCG+ PP+ double-positive cells through hyperaminoacidemia and mTOR signaling.
DOI 10.1101/2025.02.27.640454