Lucas Pinto

Patterned wireless transcranial optogenetics generates artificial perception

This paper develops a wireless transcranial optogenetic system to generate artificial perceptions in mice through controlled cortical stimulation and demonstrates its effectiveness in operant learning tasks.

A cholinergic mechanism orchestrating task-dependent computation across the cortex

This study identifies a cholinergic mechanism that modulates task-dependent cortical activity during evidence accumulation in mice.

Working memory expands shared task representations in cortex

The paper shows that working memory tasks involve a shared low-dimensional neural structure with more disjoint firing fields compared to simpler tasks, supporting cognitive processes.

Network dynamics underlying activity-timescale differences between cortical regions

The paper investigates how network dynamics differ between cortical regions with distinct activity timescales, showing that long-timescale areas sustain input over longer periods through specific neuronal recruitment patterns.

Cognitive processes are disentangled at cortex-wide scales

The paper shows that cognitive processes like evidence accumulation and memory are represented as near-orthogonal subspaces across the cortex, breaking down during errors.

Modeling communication and switching nonlinear dynamics in multi-region neural activity

This paper introduces a probabilistic model to analyze multi-region neural dynamics and communication, showing it outperforms existing models on mouse neural datasets.

Multiple timescales of sensory-evidence accumulation across the dorsal cortex

The paper investigates how different cortical areas contribute to sensory evidence accumulation by manipulating their activity and observing changes in decision-making.

Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

The paper shows that dorsomedial striatal pathways oppositely control behavior depending on task demands and internal state.

An accumulation-of-evidence task using visual pulses for mice navigating in virtual reality

This paper introduces a new evidence-accumulation task for mice in virtual reality, showing they accumulate visual evidence to make decisions, with performance influenced by evidence magnitude but not duration.