Stephan Y. Thiberge

High-speed whole-brain imaging in Drosophila

This paper introduces light beads microscopy (LBM) to enable high-speed volumetric imaging of Drosophila brains, revealing fast neural responses to auditory stimuli.

Single-Cell Perturbations Reveal Selective Modulation of Causal Connectivity During Decision-Making

The paper investigates how cortical connectivity changes during different phases of a decision-making task in mice, finding phase-specific modulation of causal connectivity.

Working memory expands shared task representations in cortex

The paper shows that working memory tasks involve a shared low-dimensional neural structure with more disjoint firing fields compared to simpler tasks, supporting cognitive processes.

Error-driven changes in hippocampal representations accompany flexible re-learning

The paper shows error-driven drift in hippocampal representations enables flexible re-learning by allowing new associations to form while maintaining previous ones in synaptic weights.

TWINKLE: An open-source two-photon microscope for teaching and research

The paper introduces TWINKLE, an open-source two-photon microscope designed for both teaching and research, highlighting its ease of setup and educational applications.

BIFROST: a method for registering diverse imagingdatasets of the Drosophila brain

BIFROST registers diverse Drosophila brain imaging datasets into a common anatomical space, enabling cross-experiment and cross-modality comparisons with sub-10 micron precision.

Magnetic voluntary head-fixation in transgenic rats enables lifetime imaging of hippocampal neurons

The paper introduces a magnetic voluntary head-fixation system for longitudinal imaging of hippocampal neurons in transgenic rats.

Overlapping representations of food and social stimuli in VTA dopamine neurons

The paper shows that VTA dopamine neurons respond to both food and social stimuli, with overlapping populations and increased overlap under hunger or social experience.

Sequential and efficient neural-population coding of complex task information

The paper investigates how neural populations encode complex task information efficiently and sequentially in mice, finding that task variables are represented by uncorrelated neural modes and that encoding is multiplexed with sequential dynamics.

Auditory Activity is Diverse and Widespread Throughout the Central Brain of Drosophila

The paper uses volumetric neural imaging to study auditory activity across the entire central brain of Drosophila, finding widespread and modality-general responses tuned to courtship song.

Chemical signatures of human odour generate a unique neural code in the brain of Aedes aegypti mosquitoes

The paper shows that human odour activates unique combinations of olfactory glomeruli in Aedes aegypti mosquitoes, with a specific glomerulus tuned to long-chain aldehydes found in human skin lipids.

Amplitude modulations of sensory responses, and deviations from Weber's Law in pulsatile evidence accumulation

The paper investigates how mice accumulate visual evidence during decision-making and finds that neural responses show amplitude modulations and deviations from Weber's Law, suggesting a feedback-based accumulation mechanism.

Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors

The paper identifies neurons in Drosophila that detect acoustic signals and drive sex-specific behaviors by linking auditory perception to behavioral responses.

Specialized and spatially organized coding of sensory, motor, and cognitive variables in midbrain dopamine neurons

The paper investigates how midbrain dopamine neurons encode sensory, motor, and cognitive variables during a complex decision-making task, finding that neurons are functionally and spatially organized into clusters specialized for specific behavioral variables.

Neural Correlates of Cognition in Primary Visual versus Neighboring Posterior Cortices during Visual Evidence-Accumulation-based Navigation

The paper shows that neural activity in visual cortices during navigation tasks encodes cognitive variables and is modulated by accumulated evidence, explaining deviations from Weber-Fechner Law.

An accumulation-of-evidence task using visual pulses for mice navigating in virtual reality

This paper introduces a new evidence-accumulation task for mice in virtual reality, showing they accumulate visual evidence to make decisions, with performance influenced by evidence magnitude but not duration.

Volumetric Two-photon Imaging of Neurons Using Stereoscopy (vTwINS)

This paper introduces vTwINS, a volumetric two-photon calcium imaging method that increases the number of neurons recorded while maintaining high frame-rate in mouse brain regions.