Sue Ann Koay

Universal Geometry of Compositional Construction in Prefrontal Cortex

This study shows rats use hierarchical composition to construct adaptive action sequences in an open-ended setting, with prefrontal neural representations following a universal geometric format.

Encoding of cerebellar dentate neuronal activity during visual attention in rhesus macaques

This study examines cerebellar dentate nucleus neuronal activity during a visual attention task in rhesus macaques, revealing dynamic encoding of visual stimuli and task-related behavior.

Detecting and Correcting False Transients in Calcium Imaging

The paper identifies and corrects misattribution errors in calcium imaging by developing a metric, visualization tool, and robust estimator for large datasets.

Sequential and efficient neural-population coding of complex task information

The paper investigates how neural populations encode complex task information efficiently and sequentially in mice, finding that task variables are represented by uncorrelated neural modes and that encoding is multiplexed with sequential dynamics.

Amplitude modulations of sensory responses, and deviations from Weber's Law in pulsatile evidence accumulation

The paper investigates how mice accumulate visual evidence during decision-making and finds that neural responses show amplitude modulations and deviations from Weber's Law, suggesting a feedback-based accumulation mechanism.

Specialized and spatially organized coding of sensory, motor, and cognitive variables in midbrain dopamine neurons

The paper investigates how midbrain dopamine neurons encode sensory, motor, and cognitive variables during a complex decision-making task, finding that neurons are functionally and spatially organized into clusters specialized for specific behavioral variables.

Neural Correlates of Cognition in Primary Visual versus Neighboring Posterior Cortices during Visual Evidence-Accumulation-based Navigation

The paper shows that neural activity in visual cortices during navigation tasks encodes cognitive variables and is modulated by accumulated evidence, explaining deviations from Weber-Fechner Law.

CaImAn: An open source tool for scalable Calcium Imaging data Analysis

CaImAn, an open-source library, automates motion correction, source extraction, deconvolution and cross-session registration for calcium imaging, detecting neurons near human level (F1 0.75 batch, 0.76 online).

A cerebellar role in evidence-guided decision-making

This study shows that the lateral posterior cerebellum contributes to perceptual decision-making by encoding choice and evidence-related variables, with dendritic calcium spikes linked to decision errors.

An accumulation-of-evidence task using visual pulses for mice navigating in virtual reality

This paper introduces a new evidence-accumulation task for mice in virtual reality, showing they accumulate visual evidence to make decisions, with performance influenced by evidence magnitude but not duration.

Predictive Coding of Novel versus Familiar Stimuli in the Primary Visual Cortex

The paper investigates predictive coding in the primary visual cortex by analyzing neural responses to novel and familiar stimuli in mice, finding a two-channel code for stimulus identity.

Volumetric Two-photon Imaging of Neurons Using Stereoscopy (vTwINS)

This paper introduces vTwINS, a volumetric two-photon calcium imaging method that increases the number of neurons recorded while maintaining high frame-rate in mouse brain regions.