Manuel Schottdorf

NeuroDisco: Interfacing neuronal populations - cell by cell, millisecond by millisecond, day by day

NeuroDisco provides optogenetic stimulation to neuronal cultures to reduce synchronized bursting and enable functional analysis of neuronal activity.

The geometry of knowledge in the hippocampal-prefrontal system

The paper shows that neural manifolds in the medial prefrontal cortex and hippocampus represent task variables as smooth gradients in low-dimensional space, with time-aligned geometry across brain areas.

Neural circuit models for evidence accumulation through choice-selective sequences

The paper develops two neural circuit models for evidence accumulation through sequential neuronal activity and tests them against neural recordings from four brain regions during a decision-making task.

Working memory expands shared task representations in cortex

The paper shows that working memory tasks involve a shared low-dimensional neural structure with more disjoint firing fields compared to simpler tasks, supporting cognitive processes.

Canonical Representational Mapping for Cognitive Neuroscience

This paper introduces Canonical Representational Mapping (CRM), a method to identify neural patterns aligned with cognitive hypotheses, validated through simulations and applied to neurophysiological datasets.

Striatal pathways oppositely shift cortical activity along the decision axis

The paper investigates how direct and indirect basal ganglia pathways influence cortical activity during decision-making, finding that they oppositely modulate a subset of neurons encoding decision variables.

TWINKLE: An open-source two-photon microscope for teaching and research

The paper introduces TWINKLE, an open-source two-photon microscope designed for both teaching and research, highlighting its ease of setup and educational applications.

Data science and its future in large neuroscience collaborations.

The paper surveys data science practices in neuroscience collaborations to identify challenges and propose improvements in data management and training.