Cristian A. Droppelmann

This study identifies ARPP21 as a TDP-43-independent aggregation pathway in ALS, showing its role in forming non-ubiquitinated aggregates and promoting intercellular propagation.

The paper shows TDP-43 and RGNEF regulate axon guidance genes through their opposing effects on long-intron processing in neuronal-like cells.

This study shows that expressing a RGNEF N-terminal fragment mitigates TDP-43 toxicity in ALS models by reducing aggregation and neurodegeneration.