Anne F. Simon

A novel function of neuroligin 3: Beyond sociality, Regulating lifespan in Drosophila

This study shows that reducing neuroligin 3 in Drosophila extends lifespan and alters social behavior, linking synaptic function to longevity.

Neuroligin 3 highlights sexually dimorphic circuitry in Drosophila social spacing

This study identifies sex-specific neural circuits involving Nlg3, MB, and fruP1 neurons that regulate social spacing in Drosophila.

Context-dependent modulation of social space by dopamine receptors in the Drosophila melanogaster mushroom body

The paper investigates how dopamine receptors in the Drosophila mushroom body regulate social spacing, finding distinct effects based on receptor type, sex, and brain region.

Deciphering the circular RNAs landscape in amyotrophic lateral sclerosis

This study identifies circRNAs involved in ALS and related motor neuron diseases, showing their regulatory roles through miRNA sponging and interactions with RNA-binding proteins.

Recovery from social isolation requires dopamine in males, but not the autism-related gene nlg3 in either sex

This study shows that dopamine, but not the autism-related gene nlg3, is required for male vinegar flies to recover from social isolation, with sex-specific effects on dopamine levels.

Mitigation of TDP-43-induced toxic phenotype by expression of RGNEF N-terminal fragment in ALS models

This study shows that expressing a RGNEF N-terminal fragment mitigates TDP-43 toxicity in ALS models by reducing aggregation and neurodegeneration.

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies

This paper investigates the effects of altering lactate metabolism in Drosophila neurons and glia on aging and memory, finding age-dependent impacts on survival and memory.