This study identifies the role of cardiolipin synthase and the LiaFSR system in daptomycin resistance by redistributing anionic phospholipids in Enterococcus faecalis.

16 citations

bacteria (other)proteomics

𝕏 PostBluesky

MicrobiologyThe Journal of Infectious DiseasesPeer-reviewedApr 3, 2024

Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis

William R. Miller, April H. Nguyen, Kavindra V. Singh…·César A. Arias

This study identifies the MadRS system and its operon madEFG as mediators of resistance to antimicrobial peptides and antibiotics in Enterococcus faecalis, linking membrane lipid changes to stress response and virulence.

16 citations

bacteria (other)genetic perturbation / CRISPR

𝕏 PostBluesky

MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedJan 30, 2024

LiaX is a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium

Dierdre B. Axell‐House, Shelby R. Simar, Diana Panesso…·César A. Arias

This study identifies LiaX as a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium and validates its use through ELISA and genomic analysis of clinical isolates.

13 citations

E. coliproteomics

𝕏 PostBluesky