Author

Alexander S. Dowdell

Veterans Health AdministrationORCID 0000-0002-0513-6623Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Rebecca L. RoeriD· 3 shared Sean P. ColganiD· 3 shared Corey S. WorledgeiD· 2 shared Geetha BhagavatulaiD· 2 shared Ian M. CartwrightiD· 2 shared Jacob A. CountessiD· 2 shared Liheng ZhouiD· 2 shared Noah T ThompsoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersMolecular Biology

Rebecca L. RoerORCID

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3 papers

Recent·Most cited

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedApr 9, 2026

Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa

Alfredo Ornelas, Jacob A. Countess, Ji Yeon Kim…·Sean P. Colgan

This study identifies a butyrate analog, 3-chlorobutyrate, that enhances epithelial barrier formation and is protective in colitis without affecting intestinal stem cells.

3 citationstop 3%

mousebulk RNA-seq

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MicrobiologybioRxivPreprintMay 28, 2025

Proton motive force as a driver of persister sensitization by adenosine

Noah T Thompson, David Kitzenberg, Alexander S. Dowdell…·Daniel J. Kao

This paper identifies adenosine metabolism as a mechanism that enhances antibiotic sensitivity by increasing proton motive force and cytoplasmic alkalinization in bacteria.

2 citations

bacteria (other)metabolomics

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Cell BiologybioRxivPreprintMay 14, 2025

Regulation of Epithelial HIF by Probiotic Escherichia coli

Alexander S. Dowdell, Rebecca L. Roer, Geetha Bhagavatula…·Sean P. Colgan

This study shows that probiotic E. coli stabilizes HIF in intestinal epithelial cells, promoting a pro-barrier transcriptional program through aerobic respiration, and induces tissue hypoxia in vivo.

1 citation

mousebulk RNA-seq

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