Sean P. Colgan

This study identifies eosinophil-derived COX-2 and PGE2 as critical regulators of IL-22 production during colitis, revealing a protective eosinophil-ILC3 crosstalk that safeguards the intestinal barrier.

This study identifies a butyrate analog, 3-chlorobutyrate, that enhances epithelial barrier formation and is protective in colitis without affecting intestinal stem cells.

This study shows that mitochondrial ATP production, induced by D-α-hydroxybutyrate, promotes T cell differentiation and function by regulating chromatin accessibility and gene expression.

This study shows that epithelial HO-1 promotes colonic tumorigenesis in chronic inflammation by increasing iron availability and oxidative stress, while protecting against acute heme toxicity.

This paper identifies adenosine metabolism as a mechanism that enhances antibiotic sensitivity by increasing proton motive force and cytoplasmic alkalinization in bacteria.

This study shows that probiotic E. coli stabilizes HIF in intestinal epithelial cells, promoting a pro-barrier transcriptional program through aerobic respiration, and induces tissue hypoxia in vivo.