Author

David M. A. Mann

University of ManchesterORCID 0000-0002-3960-9863Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:GWAS summary statistics· 2 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Andrew RobinsoniD· 3 shared Abhay KotechaiD· 2 shared Airi TarutaniiD· 2 shared Alberto LleóiD· 2 shared Dena G. HernandeziD· 2 shared Ekaterina A. RogaevaiD· 2 shared Glenda Margaret HallidayiD· 2 shared John HardyiD· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Andrew RobinsonORCID

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Author profile →

5 papers

Recent·Most cited

Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, David M. A. Mann, Andrew Robinson, , Takaomi C. Saido

This paper investigates the metabolic stability and deposition of A{beta}3pE-42, a target of the Alzheimer's antibody donanemab, showing it is more stable than other A{beta}X-42 species and accumulates with age.

Life Science Alliance · Sep 30, 2024Peer-reviewedNeuroscience

Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration

Airi Tarutani, Sofia Lövestam, Xianjun Zhang, Abhay Kotecha, Andrew Robinson, David M. A. Mann, Yuko Saito, Shigeo Murayama, Taisuke Tomita, Michel Goedert, Sjors H. W. Scheres, Masato Hasegawa

The paper reports cryo-EM structures of tau filaments formed in SH-SY5Y cells seeded with brain extracts from Alzheimer's and corticobasal degeneration cases, showing some structural templating.

FEBS Open Bio · Jun 20, 2023Peer-reviewedNeuroscience

Structure-based Classification of Tauopathies

Yang Shi, Wenjuan Zhang, Yang Yang, Alexey G. Murzin, Benjamin Falcon, Abhay Kotecha, M. van Beers, Airi Tarutani, Fuyuki Kametani, Holly J. Garringer, Rubén Vidal, Grace I. Hallinan, Tammaryn Lashley, Yuko Saito, Shigeo Murayama, , Sjors H. W. Scheres

Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.

Nature · Sep 29, 2021Peer-reviewedNeuroscience✦ In-depth digest

Heritability and genetic variance of dementia with Lewy bodies

Rita João Guerreiro, Valentina Escott‐Price, Dena G. Hernandez, Célia Kun‐Rodrigues, Owen A. Ross, Tatiana Orme, João Luís Neto, Susana Carmona, Nadia Dehghani, John D. Eicher, Claire E. Shepherd, Laura Parkkinen, Lee Darwent, Michael G. Heckman, Sonja W. Scholz, , José Brás

This study estimates the heritability of dementia with Lewy bodies (DLB) and finds it to be higher than previous estimates, with low variance explained by polygenic risk scores from Parkinson's or Alzheimer's disease.

Neurobiology of Disease · Apr 3, 2019Peer-reviewedNeuroscience

CXCR4 involvement in neurodegenerative diseases

Luke W. Bonham, Celeste M M. Karch, Chun Chieh Fan, Chin Hong Tan, Ethan G. Geier, Yunpeng Wang, Natalie Wen, Iris Broce, Yi Li, Matthew J. Barkovich, Raffaele Ferrari, John Hardy, Parastoo Momeni, Günter U. Höglinger, Ulrich Müller, , Murray Grossman

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

Translational Psychiatry · Apr 11, 2018Peer-reviewedGenetics