Guorong Wu A

This study identifies molecular layer heterotopias and age-dependent cortical expansion in Chd8 haploinsufficient mice, linking them to neuronal migration defects and autism-related brain overgrowth.

CellPheno is a 3D nuclei segmentation tool for whole-brain microscopy that enables efficient morphometry and co-localization analysis across multiple cell types in mouse brains.

The paper develops PainFace, a deep learning platform for automated mouse grimace scoring, showing it outperforms humans in speed and data generation, and identifies pain-related facial expressions.

Segmentor is a tool for manual refinement of 3D microscopy annotations, improving efficiency without sacrificing accuracy.

NuMorph quantifies nuclei and nuclear markers in cleared mouse brain images, revealing gene deletion effects on cell-type distribution and brain morphology in two mouse models.