A self-limiting mechanotransduction feedback loop ensures robust organ formation
Yusuke Mori, Paul Robin, Anne Belle Briggs, Daniel S. Levic, Jiacheng Wang, Vishank Jain-Sharma, Kira L. Heikes, Michel Bagnat, Édouard Hannezo, Akankshi Munjal
The paper shows Yap mechanotransduction creates a self-limiting feedback loop for zebrafish semicircular canal formation, integrating mechanical forces and transcriptional responses to ensure robust development.
Nature Communications · Oct 10, 2026Peer-reviewedDevelopmental Biology