Loss of Arginase 2 Promotes Lung Metastasis in immune-competent hosts via Nitric Oxide Synthase 2-Dependent Th17 Response
Shu-Ting Chou, Xiaoyong Wang, Jing Yang, Yoonha Hwang, Jiacheng Wang, Yujie Ding, Jeffrey C. Rathmell, Deanna N. Edwards, Jin Chen
This study identifies ARG2 deficiency in tumor cells as a driver of lung metastasis via NOS2-dependent Th17 responses in immune-competent hosts.
bioRxiv · Jun 8, 2026 · PreprintCancer Biology