Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic, and neurogenic responses for wound healing
Juan Carlos Palomeque Chávez, Marko Dobricic, Matthew McGrath, Cian O’Connor, Tara K. McGuire, Jack Maughan, Adrian G. Dervan, James E. Dixon, Cathal John Kearney, Shane Browne, Fergal J. O’Brien
This paper introduces a miRNA-155 inhibitor-activated scaffold that promotes anti-inflammatory, angiogenic, and neurogenic responses in chronic wounds through macrophage polarisation and nerve regeneration.
Bioactive Materials · Feb 17, 2026Peer-reviewedBioengineering