This study identifies ANPEP as upregulated in gastric adenocarcinoma and associated with immune suppression and tumor progression, suggesting its potential as a biomarker and therapeutic target.

Genetics and Molecular Biology · Jan 1, 2026Peer-reviewedCancer Biology

Immune Remodeling and Dysbiosis May Distinguish the Microenvironments of Gastric Adenocarcinoma and Peritumoral Tissue

Ronald Matheus da Silva Mourão, Juliana Barreto Albuquerque Pinto, Jéssica Manoelli Costa da Silva, Daniel de Souza Avelar, Valéria Cristiane Santos da Silva, Ana Karyssa Mendes Anaissi, Sâmia Demachki, Williams Fernandes Barra, Fabiano Cordeiro Moreira, Paulo Pimentel de Assumpção

This study compares microbial diversity, immune cell composition, and gene expression in gastric adenocarcinoma and peritumoral tissue to identify functional differences in their microenvironments.

Lecture notes in computer science · Nov 16, 2025Peer-reviewedGenetics

Dietary Patterns and Gene Expression Profiles in Gastric Adenocarcinoma Patients from the Northern Region of Brazil

Lidiany Corrêa Serrão, Valéria Cristiane Santos da Silva, Ana Karyssa Mendes Anaissi, Diego Pereira, Tayana Vago de Miranda, D. O. MACKERT, Jéssica Manoelli Costa da Silva, Ana Paula Freitas de Sousa, Naiza Nayla Bandeira de Sá, Williams Fernandes Barra, Fabiano Cordeiro Moreira, Paulo Pimentel Assumpcão, Sâmia Demachki, Marília de Souza Araújo

This study examines dietary patterns in gastric adenocarcinoma patients and identifies differentially expressed genes linked to dietary risk exposure.

bioRxiv · Sep 17, 2025 · PreprintCancer Biology

Transcriptional Signatures of Field Cancerization in Gastric Cancer

Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Juliana Barreto Albuquerque Pinto, Diego Pereira, Valéria Cristiane Santos da Silva, Kaue Sant Ana Pereira Guimaraes, Ana Karyssa Mendes Anaissi, Sâmia Demachki, Williams Fernandes Barra, Samir Mansour Moraes Casseb, Fabiano Cordeiro Moreira, Rommel Mário Rodríguez Burbano, Paulo Pimentel Assumpcão

The paper identifies a 138-gene transcriptional signature in gastric cancer peritumoral tissue that is conserved in tumors and associated with poor prognosis.

bioRxiv · Sep 15, 2025 · PreprintGenetics

Transcriptomic Mutational Profiling of Gastric Adenocarcinoma in Northern Brazil

Rubem Ferreira da Silva, Diego Pereira, Mateus Silva Tavares, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Valéria Cristiane Santos da Silva, Juliana Barreto Albuquerque Pinto, Samir Mansour Moraes Casseb, Sâmia Demachki, Tatiane Neotti, Ana Karyssa Mendes Anaissi, Williams Fernandes Barra, Amanda Ferreira Vidal, Geraldo Ishak, , Fabiano Cordeiro Moreira

This study analyzes mutational profiles in gastric adenocarcinoma samples from northern Brazil using NGS, identifying key mutations and patterns associated with replication damage and DNA repair.

bioRxiv · Sep 15, 2025 · PreprintBioinformatics

Characterization of Human Endogenous Retroviruses in Gastric Cancer with Helicobacter pylori: A Study from Northern Brazil

Marcos da Conceição, Juliana Barreto Albuquerque Pinto, Diego Pereira, Rubem Ferreira da Silva, Sérgio Augusto Antunes Ramos, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Valéria Cristiane Santos da Silva, Samir Mansour Moraes Casseb, Sâmia Demachki, Tatiane Neotti, Ana Karyssa Mendes Anaissi, Williams Fernandes Barra, Amanda Ferreira Vidal, , Fabiano Cordeiro Moreira

This study characterizes HERV expression in gastric cancer tissues and finds differential expression in tumor samples, particularly those with H. pylori infection.

bioRxiv · Sep 6, 2025 · PreprintGenetics

EXPRESSION INSIGHTS INTO GASTRIC ADENOCARCINOMA: NETWORK ANALYSIS REVEALS KEY HUB GENES AND FUNCTIONAL MODULES

Ronald Matheus da Silva Mourão, Fabiano Cordeiro Moreira, Jéssica Manoelli Costa da Silva, Daniel de Souza Avelar, Valéria Cristiane Santos da Silva, Amanda Ferreira Vidal, Leandro Lopes de Magalhães, Ana Karyssa Mendes Anaissi, Sâmia Demachki, Williams Fernandes Barra, Paulo Pimentel de Assumpção

The paper uses coexpression network analysis on RNA-seq data to identify key hub genes and modules associated with gastric adenocarcinoma, revealing potential diagnostic biomarkers and tumor microenvironment interactions.

bioRxiv · Aug 27, 2025 · PreprintGenomics

Unmasking Epstein-Barr Role in Gastric Carcinogenesis: A Gene Expression Approach to Virus-Positive Tumors

Valéria Cristiane Santos da Silva, Diego Pereira, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Rubem Ferreira da Silva, Davi Josué Marcon, Leandro Lopes de Magalhães, Amanda Ferreira Vidal, Tatiane Neotti, Ana Karyssa Mendes Anaissi, Williams Fernandes Barra, Samir Mansour Moraes Casseb, Andrea Kely Campos Ribeiro dos Santos, Sâmia Demachki, , Rommel Mário Rodríguez Burbano

This study uses RNA-seq to analyze gene expression in EBV-positive and EBV-negative gastric cancer samples, identifying differentially expressed genes and viral gene activity associated with tumor progression.

bioRxiv · Jan 23, 2025 · PreprintCancer Biology