This study identifies ANPEP as upregulated in gastric adenocarcinoma and associated with immune suppression and tumor progression, suggesting its potential as a biomarker and therapeutic target.

Genetics and Molecular Biology · Jan 1, 2026Peer-reviewedCancer Biology

Dietary Patterns and Gene Expression Profiles in Gastric Adenocarcinoma Patients from the Northern Region of Brazil

Lidiany Corrêa Serrão, Valéria Cristiane Santos da Silva, Ana Karyssa Mendes Anaissi, Diego Pereira, Tayana Vago de Miranda, D. O. MACKERT, Jéssica Manoelli Costa da Silva, Ana Paula Freitas de Sousa, Naiza Nayla Bandeira de Sá, Williams Fernandes Barra, Fabiano Cordeiro Moreira, Paulo Pimentel Assumpcão, Sâmia Demachki, Marília de Souza Araújo

This study examines dietary patterns in gastric adenocarcinoma patients and identifies differentially expressed genes linked to dietary risk exposure.

bioRxiv · Sep 17, 2025 · PreprintCancer Biology

Transcriptional Signatures of Field Cancerization in Gastric Cancer

Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Juliana Barreto Albuquerque Pinto, Diego Pereira, Valéria Cristiane Santos da Silva, Kaue Sant Ana Pereira Guimaraes, Ana Karyssa Mendes Anaissi, Sâmia Demachki, Williams Fernandes Barra, Samir Mansour Moraes Casseb, Fabiano Cordeiro Moreira, Rommel Mário Rodríguez Burbano, Paulo Pimentel Assumpcão

The paper identifies a 138-gene transcriptional signature in gastric cancer peritumoral tissue that is conserved in tumors and associated with poor prognosis.

bioRxiv · Sep 15, 2025 · PreprintGenetics

Transcriptomic Mutational Profiling of Gastric Adenocarcinoma in Northern Brazil

Rubem Ferreira da Silva, Diego Pereira, Mateus Silva Tavares, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Valéria Cristiane Santos da Silva, Juliana Barreto Albuquerque Pinto, Samir Mansour Moraes Casseb, Sâmia Demachki, Tatiane Neotti, Ana Karyssa Mendes Anaissi, Williams Fernandes Barra, Amanda Ferreira Vidal, Geraldo Ishak, , Fabiano Cordeiro Moreira

This study analyzes mutational profiles in gastric adenocarcinoma samples from northern Brazil using NGS, identifying key mutations and patterns associated with replication damage and DNA repair.

bioRxiv · Sep 15, 2025 · PreprintBioinformatics

Interspecies Functional Divergence: The Microbiome's Role in FLOT Response e Across Gastric Cancer Subtypes

Dionison Pereira Sarquis, Valéria Cristiane Santos da Silva, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Tamires Tavares de Araújo, Diego Pereira, Polyana Silva de Araújo, Geraldo Ishak, Samir Mansour Moraes Casseb, Sâmia Demachki, Williams Fernandes Barra, Fabiano Cordeiro Moreira, Rommel Mário Rodríguez Burbano, Paulo Pimentel de Assumpção

This study examines how the FLOT chemotherapy regimen affects the gastric tumor microenvironment, revealing subtype-specific microbiome-host interactions that influence tumor behavior.

bioRxiv · Sep 13, 2025 · PreprintCancer Biology

Influence of Epigenetic Regulators Expression on Gastric Cancer Prognosis

Lucas Brabo Rotella, André Salim Khayat, M. F. SILVA, Victoria Pereira Costa, Diego Pereira, Fabiano Cordeiro Moreira, Sâmia Demachki, Samir Mansour Moraes Casseb, Geraldo Ishak, Williams Fernandes Barra, Rommel Mário Rodríguez Burbano, Paulo Pimentel Assumpcão

The paper analyzes epigenetic gene expression in gastric cancer samples to identify dysregulated pathways and potential biomarkers.

medRxiv · Sep 12, 2025 · PreprintGenetic & Genomic Medicine

Integrated Expression Analysis of C-MYC Oncogene-Associated Pathways in Gastric Adenocarcinoma and its Correlation with Clinicopathological Factors

Kaue Sant Ana Pereira Guimaraes, Murilo Filho Pereira Marinho, Jennifer Somtochukwu Nwoye, Ronald Matheus da Silva Mourão, Juliana Barreto Albuquerque Pinto, Jéssica Manoelli Costa da Silva, Diego Pereira, Valéria Cristiane Santos da Silva, Sâmia Demachki, Williams Fernandes Barra, Samir Mansour Casseb, Fabiano Cordeiro Moreira, Rommel Mário Rodríguez Burbano, Paulo Pimentel Assumpcão

This study analyzes the expression of C-MYC and its associated pathways in gastric adenocarcinoma, identifying dysregulated genes and their correlation with clinicopathological factors.

bioRxiv · Sep 11, 2025 · PreprintGenetics

FERROPTOSIS GENE SIGNATURES REVEAL DISTINCT REGULATORY LANDSCAPES IN GASTRIC ADENOCARCINOMA AND OTHER TISSUES

Sérgio Augusto Antunes Ramos, Thaynara Pereira de Abreu, Marcos da Conceição, Valéria Cristiane Santos da Silva, Diego Pereira, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Rubem Ferreira da Silva, Williams Fernandes Barra, Samir Mansour Moraes Casseb, Andrea Kely Campos Ribeiro dos Santos, Sâmia Demachki, Geraldo Ishak, Fabiano Cordeiro Moreira, , Paulo Pimentel de Assumpção

This study identifies distinct ferroptosis gene signatures in gastric adenocarcinoma and adjacent tissues, revealing transcriptional heterogeneity and regulatory imbalances.

bioRxiv · Sep 11, 2025 · PreprintCancer Biology

GASTRIC CANCER BASED ON TRANSCRIPTION FACTORS

Aline Gonçalves da Costa, Kaue Sant Ana Pereira Guimaraes, Ronald Matheus da Silva Mourão, Juliana Barreto Albuquerque Pinto, Jéssica Manoelli Costa da Silva, Diego Pereira, Valéria Cristiane Santos da Silva, Sâmia Demachki, Williams Fernandes Barra, Samir Mansour Moraes Casseb, Fabiano Cordeiro Moreira, Rommel Mário Rodríguez Burbano, Paulo Pimentel Assumpcão

This study identifies differentially expressed transcription factors in gastric adenocarcinoma using NGS and bioinformatics, revealing potential biomarkers for prognosis and treatment.

bioRxiv · Sep 7, 2025 · PreprintCancer Biology

Characterization of Human Endogenous Retroviruses in Gastric Cancer with Helicobacter pylori: A Study from Northern Brazil

Marcos da Conceição, Juliana Barreto Albuquerque Pinto, Diego Pereira, Rubem Ferreira da Silva, Sérgio Augusto Antunes Ramos, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Valéria Cristiane Santos da Silva, Samir Mansour Moraes Casseb, Sâmia Demachki, Tatiane Neotti, Ana Karyssa Mendes Anaissi, Williams Fernandes Barra, Amanda Ferreira Vidal, , Fabiano Cordeiro Moreira

This study characterizes HERV expression in gastric cancer tissues and finds differential expression in tumor samples, particularly those with H. pylori infection.

bioRxiv · Sep 6, 2025 · PreprintGenetics

Viral Landscape of Gastric Adenocarcinoma Reveals Clinically Relevant Viruses

Diego Pereira, Fabiano Cordeiro Moreira, Daniel de Souza Avelar, Sérgio Augusto Antunes Ramos, Valéria Cristiane Santos da Silva, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Rubem Ferreira da Silva, Kaue Sant Ana Pereira Guimaraes, Juliana Barreto Albuquerque Pinto, Marcos da Conceição, Williams Fernandes Barra, Sâmia Demachki, Samir Mansour Moraes Casseb, Rommel Mário Rodríguez Burbano, Paulo Pimentel de Assumpção

The paper identifies viral species in gastric tumor and peritumoral tissues, finding enriched viruses and comparable diversity between tissue types.

bioRxiv · Sep 5, 2025 · PreprintGenetics

Unmasking Epstein-Barr Role in Gastric Carcinogenesis: A Gene Expression Approach to Virus-Positive Tumors

Valéria Cristiane Santos da Silva, Diego Pereira, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Rubem Ferreira da Silva, Davi Josué Marcon, Leandro Lopes de Magalhães, Amanda Ferreira Vidal, Tatiane Neotti, Ana Karyssa Mendes Anaissi, Williams Fernandes Barra, Samir Mansour Moraes Casseb, Andrea Kely Campos Ribeiro dos Santos, Sâmia Demachki, , Rommel Mário Rodríguez Burbano

This study uses RNA-seq to analyze gene expression in EBV-positive and EBV-negative gastric cancer samples, identifying differentially expressed genes and viral gene activity associated with tumor progression.

bioRxiv · Jan 23, 2025 · PreprintCancer Biology