This study compares microbial diversity, immune cell composition, and gene expression in gastric adenocarcinoma and peritumoral tissue to identify functional differences in their microenvironments.

Lecture notes in computer science · Nov 16, 2025Peer-reviewedGenetics

Transcriptional Signatures of Field Cancerization in Gastric Cancer

Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Juliana Barreto Albuquerque Pinto, Diego Pereira, Valéria Cristiane Santos da Silva, Kaue Sant Ana Pereira Guimaraes, Ana Karyssa Mendes Anaissi, Sâmia Demachki, Williams Fernandes Barra, Samir Mansour Moraes Casseb, Fabiano Cordeiro Moreira, Rommel Mário Rodríguez Burbano, Paulo Pimentel Assumpcão

The paper identifies a 138-gene transcriptional signature in gastric cancer peritumoral tissue that is conserved in tumors and associated with poor prognosis.

bioRxiv · Sep 15, 2025 · PreprintGenetics

Transcriptomic Mutational Profiling of Gastric Adenocarcinoma in Northern Brazil

Rubem Ferreira da Silva, Diego Pereira, Mateus Silva Tavares, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Valéria Cristiane Santos da Silva, Juliana Barreto Albuquerque Pinto, Samir Mansour Moraes Casseb, Sâmia Demachki, Tatiane Neotti, Ana Karyssa Mendes Anaissi, Williams Fernandes Barra, Amanda Ferreira Vidal, Geraldo Ishak, , Fabiano Cordeiro Moreira

This study analyzes mutational profiles in gastric adenocarcinoma samples from northern Brazil using NGS, identifying key mutations and patterns associated with replication damage and DNA repair.

bioRxiv · Sep 15, 2025 · PreprintBioinformatics

Integrated Expression Analysis of C-MYC Oncogene-Associated Pathways in Gastric Adenocarcinoma and its Correlation with Clinicopathological Factors

Kaue Sant Ana Pereira Guimaraes, Murilo Filho Pereira Marinho, Jennifer Somtochukwu Nwoye, Ronald Matheus da Silva Mourão, Juliana Barreto Albuquerque Pinto, Jéssica Manoelli Costa da Silva, Diego Pereira, Valéria Cristiane Santos da Silva, Sâmia Demachki, Williams Fernandes Barra, Samir Mansour Casseb, Fabiano Cordeiro Moreira, Rommel Mário Rodríguez Burbano, Paulo Pimentel Assumpcão

This study analyzes the expression of C-MYC and its associated pathways in gastric adenocarcinoma, identifying dysregulated genes and their correlation with clinicopathological factors.

bioRxiv · Sep 11, 2025 · PreprintGenetics

GASTRIC CANCER BASED ON TRANSCRIPTION FACTORS

Aline Gonçalves da Costa, Kaue Sant Ana Pereira Guimaraes, Ronald Matheus da Silva Mourão, Juliana Barreto Albuquerque Pinto, Jéssica Manoelli Costa da Silva, Diego Pereira, Valéria Cristiane Santos da Silva, Sâmia Demachki, Williams Fernandes Barra, Samir Mansour Moraes Casseb, Fabiano Cordeiro Moreira, Rommel Mário Rodríguez Burbano, Paulo Pimentel Assumpcão

This study identifies differentially expressed transcription factors in gastric adenocarcinoma using NGS and bioinformatics, revealing potential biomarkers for prognosis and treatment.

bioRxiv · Sep 7, 2025 · PreprintCancer Biology

Characterization of Human Endogenous Retroviruses in Gastric Cancer with Helicobacter pylori: A Study from Northern Brazil

Marcos da Conceição, Juliana Barreto Albuquerque Pinto, Diego Pereira, Rubem Ferreira da Silva, Sérgio Augusto Antunes Ramos, Daniel de Souza Avelar, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Valéria Cristiane Santos da Silva, Samir Mansour Moraes Casseb, Sâmia Demachki, Tatiane Neotti, Ana Karyssa Mendes Anaissi, Williams Fernandes Barra, Amanda Ferreira Vidal, , Fabiano Cordeiro Moreira

This study characterizes HERV expression in gastric cancer tissues and finds differential expression in tumor samples, particularly those with H. pylori infection.

bioRxiv · Sep 6, 2025 · PreprintGenetics

Viral Landscape of Gastric Adenocarcinoma Reveals Clinically Relevant Viruses

Diego Pereira, Fabiano Cordeiro Moreira, Daniel de Souza Avelar, Sérgio Augusto Antunes Ramos, Valéria Cristiane Santos da Silva, Jéssica Manoelli Costa da Silva, Ronald Matheus da Silva Mourão, Rubem Ferreira da Silva, Kaue Sant Ana Pereira Guimaraes, Juliana Barreto Albuquerque Pinto, Marcos da Conceição, Williams Fernandes Barra, Sâmia Demachki, Samir Mansour Moraes Casseb, Rommel Mário Rodríguez Burbano, Paulo Pimentel de Assumpção

The paper identifies viral species in gastric tumor and peritumoral tissues, finding enriched viruses and comparable diversity between tissue types.

bioRxiv · Sep 5, 2025 · PreprintGenetics