Mewen Briend

The paper identifies regulatory variants associated with aortic valve disease and shows their impact on gene expression and disease mechanisms.

LaScaMolMR.jl enables efficient large-scale molecular Mendelian randomization studies by providing a fast, integrated Julia package for omic-wide MR analyses.

This paper uses Mendelian randomization to identify 49 blood proteins causally associated with calcific aortic valve disease, revealing immune and growth factor pathways involved in the disease.