Sébastien Thériault

This study shows that lipoprotein(a) promotes thrombosis by enhancing platelet activation and creating lysis-resistant thrombus structures, with effects mitigated by aspirin.

The paper identifies regulatory variants associated with aortic valve disease and shows their impact on gene expression and disease mechanisms.

This study identifies twelve novel blood pressure loci and shows smoking modifies genetic effects on BP through immune-related pathways in over 1 million individuals.

This study identifies 22 novel gene-sleep duration interaction loci for blood pressure traits across 811,405 individuals, highlighting distinct genetic influences of short and long sleep on cardiovascular health.

This paper evaluates polygenic risk scores (PRS) for CAD and blood lipids to predict CAD incidence in UK Biobank participants.

This study compares scRNA-seq and snRNA-seq in lung samples, finding differences in cell type composition and biological insights between fresh and frozen tissues.

This paper uses Mendelian randomization to identify 49 blood proteins causally associated with calcific aortic valve disease, revealing immune and growth factor pathways involved in the disease.

This study uses trans-omic Mendelian randomization to identify genes, proteins, and metabolites associated with parental lifespan and potential drug targets for healthspan extension.

This study identifies three new susceptibility genes for calcific aortic valve stenosis through GWAS and TWAS, highlighting roles in inflammation, mineralization, and blood vessel integrity.

This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.

This study investigates the association between elevated Lp(a) levels, parental lifespan, and long-term mortality risk using genetic and observational data.

This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.

The paper assesses if genetic risk for atrial fibrillation explains cardioembolic stroke risk using genome-wide data from the Stroke Genetics Network.

This study identifies 46 novel genetic loci associated with alcohol consumption and suggests shared genetic mechanisms with neuropsychiatric disorders using GWAS and functional analyses.