Patrick Mathieu

Decoding causal genes and programs from regulatory variants in aortic valve disease

The paper identifies regulatory variants associated with aortic valve disease and shows their impact on gene expression and disease mechanisms.

Association of Genetically Predicted Levels of Circulating Blood Lipids with Coronary Artery Disease Incidence

This paper evaluates polygenic risk scores (PRS) for CAD and blood lipids to predict CAD incidence in UK Biobank participants.

Efficient molecular mendelian randomization screens with LaScaMolMR.jl

LaScaMolMR.jl enables efficient large-scale molecular Mendelian randomization studies by providing a fast, integrated Julia package for omic-wide MR analyses.

Integrative Analysis of the Blood Proteome by Mendelian Randomization Reveals Regulatory Networks in Calcific Aortic Valve Disease

This paper uses Mendelian randomization to identify 49 blood proteins causally associated with calcific aortic valve disease, revealing immune and growth factor pathways involved in the disease.

Genetic control of body weight by the human brain proteome

This study identifies 71 brain proteins linked to body weight regulation through genetic analysis and shows their association with dietary intake.

A Trans-Omic Mendelian Randomization Study of Parental Lifespan Uncovers Novel Aging Biology and Drug Candidates for Human Healthspan Extension

This study uses trans-omic Mendelian randomization to identify genes, proteins, and metabolites associated with parental lifespan and potential drug targets for healthspan extension.

Genetic association analyses highlight IL6, ALPL, and NAV1 as three new susceptibility genes underlying calcific aortic valve stenosis

This study identifies three new susceptibility genes for calcific aortic valve stenosis through GWAS and TWAS, highlighting roles in inflammation, mineralization, and blood vessel integrity.

Long-Term Exposure to Elevated Lipoprotein(a) Levels, Parental Lifespan and Risk of Mortality

This study investigates the association between elevated Lp(a) levels, parental lifespan, and long-term mortality risk using genetic and observational data.

Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis

This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis