Targeting poorly differentiated thyroid cancer with bispecific antibodies and CAR T cells from the human anti-TSHR autoantibody repertoire
Claudia Fischer, Anne Eugster, Brenda Besemer, Mélanie Buchi, Marcus Bauer, Christoph Schultheiß, Elisa D’Arcangelo, Filip Filipsky, Claudia Wickenhauser, Andreas Wilfer, Kerstin Lorenz, Jens Jakscha, Laurent Müller, Roswitha Köberle-Wührer, Benjamin Kasenda, , Mascha Binder
This paper explores using anti-TSHR autoantibodies to create bispecific antibodies and CAR T cells for treating poorly differentiated thyroid cancer, showing potent in vitro and in vivo activity.
bioRxiv · Oct 20, 2026 · PreprintCancer Biology