Defining the genetic determinants of CD8+ T cell receptor repertoire in the context of immune checkpoint blockade
Esther S. Ng, Gusztav Milotay, Orion Tong…·Yang Luo
The paper identifies genetic determinants of CD8+ T cell receptor (TCR) repertoire in cancer patients before and after immune checkpoint blockade (ICB) treatment, finding associations with HLA alleles and treatment response.