Defining the genetic determinants of CD8+ T cell receptor repertoire in the context of immune checkpoint blockade
Esther S. Ng, Gusztav Milotay, Orion Tong, Chelsea Alice Taylor, Shawn Sun, Guangyi Niu, Robert A. Watson, Bo Sun, Sophie MacKay, James J. Gilchrist, Martin Little, Benjamin Peter Fairfax, Yang Luo
The paper identifies genetic determinants of CD8+ T cell receptor (TCR) repertoire in cancer patients before and after immune checkpoint blockade (ICB) treatment, finding associations with HLA alleles and treatment response.
Science Advances · Jul 25, 2025Peer-reviewedGenetics