Hai Fang

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

This study investigates the genetic and phenotypic associations between endometriosis and 31 immunological diseases using UK Biobank data, finding significant genetic correlations and a causal link with rheumatoid arthritis.

The paper identifies trained immunity in AS monocytes and shows their enhanced response to T-cell activation, contributing to Th17 responses and disease pathology.

The paper characterizes genetic determinants of context-specific DNA methylation in primary monocytes exposed to inflammatory stimuli, identifying 209 CpGs under genetic control and linking them to disease.

The paper presents a genetics-first framework using molecular knowledge to predict phenotypes from rare coding variants in a direct-to-consumer genotype cohort, identifying novel genetic causes for developmental disorders.

The paper reports results from the CAFA3 challenge, showing improved computational protein function prediction and new annotations for over 1000 genes through experimental screens in C. albicans, P. aureginosa, and Drosophila.