FASN Inhibition Resensitizes Chordoma to Radiotherapy by Targeting Adaptive Unsaturated Fatty Acid Metabolism
Ruolun Wei, Yifan Meng, Emon Nasajpour, Dena Panovska, Helena Oft, Yao Lulu Xing, Christine K Lee, Juan Carlos Fernandez-Miranda, Matei A. Banu, Richard N. Zare, Claudia Katharina Petritsch
This study shows that FASN inhibition restores radiosensitivity in chordoma by targeting adaptive fatty acid metabolism that protects against radiotherapy-induced damage.
bioRxiv · May 14, 2026 · PreprintCancer Biology