Yao Lulu Xing

FASN Inhibition Resensitizes Chordoma to Radiotherapy by Targeting Adaptive Unsaturated Fatty Acid Metabolism

This study shows that FASN inhibition restores radiosensitivity in chordoma by targeting adaptive fatty acid metabolism that protects against radiotherapy-induced damage.

HB-EGF and EGF infusion following CNS demyelination mitigates age-related decline in regeneration of oligodendrocytes from neural precursor cells originating in the ventricular-subventricular zone

This study shows that infusing HB-EGF and EGF into aged mice improves oligodendrocyte regeneration from NPCs after CNS demyelination.

High-Efficiency Pharmacogenetic Ablation of Oligodendrocyte Progenitor Cells in the Adult Mouse CNS

This paper develops a pharmacogenetic model to ablate oligodendrocyte progenitor cells (OPCs) in adult mice, achieving 98.6% depletion and revealing compensatory mechanisms from V-SVZ-derived NPCs.

5' transgenes drive leaky expression of 3' transgenes in inducible bicistronic vectors

The paper investigates leaky expression of 3' transgenes in bicistronic vectors and shows that 5' transgenes can drive promoter-like activity, leading to Cre-independent expression.