Claudia Katharina Petritsch

Isolation of postnatal human neural stem cells

The paper isolates and characterizes two postnatal human neural stem cell subsets, showing their fate biases and decline in frequency over time.

FASN Inhibition Resensitizes Chordoma to Radiotherapy by Targeting Adaptive Unsaturated Fatty Acid Metabolism

This study shows that FASN inhibition restores radiosensitivity in chordoma by targeting adaptive fatty acid metabolism that protects against radiotherapy-induced damage.

Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotype

The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.

Colorectal cancer relies on an immunosuppressive cellular topography and genomic adaptations for establishing brain metastases

This study identifies the immunosuppressive cellular and genomic features of colorectal cancer brain metastases and their mechanisms of adaptation.

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

This study identifies functional GABAergic neuron-to-glioma synapses in diffuse midline gliomas that promote tumor proliferation and shows that drugs modulating GABAergic signaling affect glioma growth.