Jan K. Buitelaar

Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium

This study analyzes fMRI data from OCD patients and controls to identify age-specific differences in brain activation during inhibitory control and error processing.

The Regional Vulnerability Index (RVI) as a Neuroimaging-Based Biomarker for Autism: Associations with Likelihood, Cognition, and Longitudinal Social Outcomes

The paper develops and evaluates the Regional Vulnerability Index (RVI-ASD) as a neuroimaging biomarker for autism, showing its stability, heritability, and associations with cognition and social outcomes.

Thalamic Nuclei Volumes Across Psychiatric and Neurological Disorders: A Multi-Site Magnetic Resonance Imaging Study

This study compares thalamic nucleus volumes across multiple psychiatric and neurological disorders using MRI, finding significant volume reductions in specific regions associated with different conditions.

Genome-Wide Association Analysis of Tic Disorders Reveals 6 Independent Risk Loci and Highlights Tic-Associated Cell Types and Brain Circuitry

This study identifies six genome-wide significant risk loci for tic disorders and links genetic risk to specific brain cell types and circuits.

A normative reference for large-scale human brain dynamics across the lifespan

The paper establishes a normative reference for large-scale human brain dynamics using resting-state fMRI data from over 10,000 individuals, revealing systematic reorganization across development and ageing and disorder-specific deviations in mental health conditions.

Brain Age in Conduct Disorder: A Mega-Analysis of the ENIGMA Antisocial Behavior Working Group

This study investigates brain age differences in youth with conduct disorder compared to controls, finding accelerated brain maturation in those with adolescence-onset CD.

Linking White-Matter Development to Clinical Variation in Autism: Longitudinal Normative Modelling of FA in the EU-AIMS LEAP Cohort

This study uses longitudinal normative modelling of white matter fractional anisotropy in the EU-AIMS LEAP cohort to show individual deviations in white matter development are linked to clinical variation in autism, with significant cross-sectional and longitudinal brain-behaviour associations.

LEAP-InovAND a multiscale resource to explore genetics, brain imaging and clinical data in autism

The paper introduces a multiscale resource integrating genetics, brain imaging, and clinical data from autistic individuals and their relatives to explore genetic and neurobiological patterns in autism.

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

Mapping neurogenetic characteristics of psychopathological procrastination using normative modeling in a prospective twin cohort

The paper identifies neurogenetic substrates of psychopathological procrastination using twin cohort data and neuroimaging analysis, revealing brain disorder characteristics.

Typical neural adaptation for familiar images in autistic adolescents

The paper investigates neural adaptation to familiar images in autistic adolescents and finds no significant difference in behavioral or neural responses compared to non-autistic adolescents.

Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity derived biomarkers

This study shows that including zero-phase-delay connectivity improves the reliability and prognostic ability of functional connectivity metrics in neural populations.

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Qualitative EEG abnormalities signal a shift towards inhibition-dominated brain networks. Results from the EU-AIMS LEAP studies

The paper examines EEG abnormalities in ASD and controls, finding reduced fE/I in both groups with abnormalities, suggesting inhibition-dominated networks in sensory regions.

Brain-Age Prediction: Systematic Evaluation of Site Effects, and Sample Age Range and Size

The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

Structural models of genome-wide covariance identify multiple common dimensions in autism

The paper uses structural equation modeling to identify three genetic factors linked to language/cognition, behavior, and motor development in ASD, revealing novel associations and simplex-specific genetic overlaps.

Linking functional and structural brain organisation with behaviour in healthy adults

The paper uses multimodal MRI data to explore brain-behavior relationships, finding some components linked to intoxication and working memory but no significant shared variance between structural and functional organisation.

Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits

The paper maps functional connectivity patterns in the somatosensory cortex during rest and emotional tasks in ASD and neurotypical individuals, linking them to adaptive functioning skills.

A comparison of bioinformatics pipelines for compositional analysis of the human gut microbiome

This paper compares five bioinformatics pipelines for analyzing 16S rRNA gene sequencing data from the gut microbiome, showing how pipeline choice affects downstream statistical results and case-control conclusions.

Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure

The paper investigates the relationship between glutamate and GABA gene-sets, autism symptoms, and cortical thickness using data from the EU-AIMS LEAP cohort.

Patterns of connectome variability in autism across five functional activation tasks. Findings from the LEAP project

The paper identifies patterns of neural variability in autism using fMRI across tasks, finding greater global connectivity deviations and similar spatial patterns in autistic individuals compared to controls.

Multilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

The paper identifies a shared cortical morphology dimension across six psychiatric conditions using MRI data from 28,546 participants.

Autism is associated with inter-individual variations of gray and white matter morphology

The paper identifies a multimodal brain pattern associated with autism by integrating gray and white matter morphology data and linking it to clinical symptoms.

Variation in glutamate and GABA genes and their association with brain structure and chemistry in autism

This study investigates the association between genetic variation in glutamate and GABA genes and brain structure/chemistry in autism, finding differential involvement in specific brain regions.

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

The paper examines age-related variations in cortical thickness across different life stages using gene expression data from a large neuroimaging dataset.

Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

The paper investigates genetic overlaps between neuropsychiatric disorders and insulin-related diseases, finding significant genetic correlations and suggesting potential clusters of disorders with divergent pleiotropic effects.

Dorsal to ventral imbalance in the superior longitudinal fasciculus mediates methylphenidate's effect on beta oscillations in ADHD

Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium

The paper examines hemispheric asymmetry in structural covariance networks in ASD across 43 datasets, finding altered topological features in specific brain regions.

Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities

The paper investigates how molecular and connectomic vulnerabilities contribute to cortical abnormalities across multiple brain disorders using MRI data from 47,000 individuals.