Author

Lei Li

Carnegie Mellon UniversityORCID 0000-0002-0688-9619Unclaimed ORCID profile · follow to get notified of new preprints

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Lei Li11 papers · University of Electronic Science and Technology of China

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:large language model· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Huichong LiuiD· 1 shared Yang YangiD· 1 shared Yunlong Zhao· 1 shared Zhenqiao SongiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBioinformatics

Huichong LiuORCID

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintMar 31, 2026

Co-designing sequence and structure of functional de novo enzymes with EnzyGen2

Zhenqiao Song, Huichong Liu, Yunlong Zhao…·Lei Li

EnzyGen2 co-designs protein sequences and structures with ligand-guided functionality, outperforming existing methods in in silico benchmarks and generating active enzymes with high novelty.

1 citation

protein sequencelarge language model

𝕏 PostBluesky