Author

Yunlong Zhao

University of California, Santa Barbara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Huichong LiuiD· 2 shared Yang YangiD· 2 shared Binh Khanh MaiiD· 1 shared Chao WangiD· 1 shared Ding ZhangiD· 1 shared Ian A. WilsoniD· 1 shared James C. PaulsoniD· 1 shared Jaroslav ŽákiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

Huichong LiuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multicatalytic cooperativity enables divergent photobiocatalytic C-C couplings for scaffold diversification

Liu-Peng Zhao, Binh Khanh Mai, Rui Guo, Lei Cheng, Huichong Liu, Yunlong Zhao, Peng Liu, Yang Yang

This study identifies new photobiocatalytic C-C couplings by combining PLP enzymes with photocatalysts, enabling the synthesis of non-canonical amino acids through directed evolution.

Nature Catalysis · Oct 28, 2026Peer-reviewedBiochemistry

Co-designing sequence and structure of functional de novo enzymes with EnzyGen2

Zhenqiao Song, Huichong Liu, Yunlong Zhao, Yang Yang, Lei Li

EnzyGen2 co-designs protein sequences and structures with ligand-guided functionality, outperforming existing methods in in silico benchmarks and generating active enzymes with high novelty.

bioRxiv · Mar 31, 2026 · PreprintBioinformatics

Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9

Chao Wang, Yingqin Hou, Jaroslav Žák, Qinheng Zheng, Kelli A. McCord, Mengyao Wu, Ding Zhang, Shereen Chung, Yujie Shi, Jinfeng Ye, Yunlong Zhao, Stephanie Hajjar, Ian A. Wilson, James C. Paulson, John Ross Teijaro, , Peng Wu

This study develops a degrader for Siglec-7 and -9 to reshape the tumor microenvironment and enhance T cell anti-tumor immunity in murine models.

bioRxiv · Oct 11, 2024 · PreprintImmunology