Lei Li

Monounsaturated fat prevent, whereas saturated fat promote, cholesterol crystals in cytoplasmic lipid droplets

This study shows monounsaturated fats reduce cholesterol crystals in lipid droplets, while saturated fats promote their formation in mice with MASH.

Establishment of Rabbit Formative-like Pluripotent Cells by Bidirectional Modulation of WNT Signaling Pathway

This paper establishes a culture system called KFiC to generate and maintain formative-like pluripotent rabbit embryonic stem cells with developmental plasticity and cross-species compatibility.

Receptor-like kinase RLK15 binds a fungal RNase effector to enhance autophosphorylation and activate host defense

The paper identifies a fungal RNase effector recognized by a plant receptor kinase, triggering immune responses and enhancing disease resistance.

Dynamic Gating Mechanism of the b0,+AT-Mediated Arg Transport: Insights from ASMD Simulations

This paper identifies residue W230 as a dynamic gate in b0,+AT that regulates arginine transport through side chain flipping, using molecular dynamics simulations.

PantheonOS: An Evolvable Multi-Agent Framework for Automatic Genomics Discovery

PantheonOS introduces a multi-agent framework for automated genomics analysis, achieving super-human performance in batch correction and gene panel selection across diverse biological tasks.

Quantitative Multicolored Deep Imaging of Human Bones Reveals a Composite Osteo-Sinusoidal Niche for Mesenchymal Stromal Cells.

The paper uses a tissue-clearing protocol to spatially map BM-MSCs in human bones, revealing distinct microenvironment features in young and aged bones.

China Autism Brain Imaging Consortium: Charting Brain Growth in Chinese Children with Autism

The paper introduces CABIC, a dataset of MRI scans from Chinese autistic and typically developing children, revealing distinct brain growth patterns and highlighting ethnic and cultural differences in neurodevelopment.

Single-cell RNA-seq reveals altered plasma cell subsets and decreased cytotoxicity of NK cells in patients with Kawasaki diseas

This study uses scRNA-seq to analyze PBMCs in KD patients and healthy controls, identifying altered B cell subsets and reduced NK cell cytotoxicity.

Mother-child dyadic interactions shape children's social brain and theory of mind

The paper examines how age and parental caregiving influence social brain development and Theory of Mind in children through naturalistic fMRI studies of mother-child dyads.

Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets

This study shows that SOAT1-mediated cholesterol esterification is required for cholesterol crystal formation in hepatocyte lipid droplets, linking it to MASH pathogenesis.

AAV11 permits efficient retrograde targeting of projection neurons

The paper identifies rAAV11 as a highly efficient retrograde tracer for projection neurons, with improved transduction and utility for neural circuit monitoring and astrocyte targeting.