Author

Huichong Liu

University of California, Santa BarbaraORCID 0009-0005-8085-7833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:large language model· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Yang YangiD· 2 shared Yunlong Zhao· 2 shared Binh Khanh MaiiD· 1 shared Lei ChengiD· 1 shared Lei LiiD· 1 shared Liu-Peng ZhaoiD· 1 shared Peng LiuiD· 1 shared Rui GuoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

Yang YangORCID

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2 papers

Recent·Most cited

BiochemistryNature CatalysisPeer-reviewedOct 28, 2026

Multicatalytic cooperativity enables divergent photobiocatalytic C-C couplings for scaffold diversification

Liu-Peng Zhao, Binh Khanh Mai, Rui Guo…·Yang Yang

This study identifies new photobiocatalytic C-C couplings by combining PLP enzymes with photocatalysts, enabling the synthesis of non-canonical amino acids through directed evolution.

DOI 10.1038/s41929-026-01629-1

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BioinformaticsbioRxivPreprintMar 31, 2026

Co-designing sequence and structure of functional de novo enzymes with EnzyGen2

Zhenqiao Song, Huichong Liu, Yunlong Zhao…·Lei Li

EnzyGen2 co-designs protein sequences and structures with ligand-guided functionality, outperforming existing methods in in silico benchmarks and generating active enzymes with high novelty.

1 citation

protein sequencelarge language model

𝕏 PostBluesky